creatine...

[klaus]

J Sports Med Phys Fitness 2000 Dec;40(4):336-42







Acute creatine loading enhances human growth hormone secretion.



Schedel JM, Tanaka H, Kiyonaga A, Shindo M, Schutz Y

Laboratory of Exercise Physiology and Biomechanics, Graduate School of Physical Education, Chukyo University, Toyota, Japan. Jean-Marc.Schedel@iphysiol.unil.ch



BACKGROUND: The main objective of this study was to explore the effect of acute creatine (Cr) ingestion on the secretion of human growth hormone (GH). METHODS: In a comparative cross-sectional study, 6 healthy male subjects ingested in resting conditions a single dose of 20 g creatine (Cr-test) vs a control (c-test). During 6 hours the Cr, creatinine and GH concentrations in blood serum were measured after Cr ingestion (Cr-test). RESULTS: During the Cr-test, all subjects showed a significant stimulation of GH (p<0.05), but with a large interindividual variability in the GH response: the difference between Cr-test and c-test averaged 83% (SD 45%). For the majority of subjects the maximum GH concentration occurred between 2 hrs and 6 hrs after the acute Cr ingestion. CONCLUSIONS: In resting conditions and at high dosages Cr enhances GH secretion, mimicking the response of strong exercise which also stimulates GH secretion. Acute body weight gain and strength increase observed after Cr supplementation should consider the indirect anabolic property of Cr.

[Hermann]

[Bortas]

[Hermann]

...250g Hähnchenbrust geschafft. Ich glaube, die reichen nicht für gewünschte Effekte )



mfg

Hermann

[kurt]

hallo klaus,

und was hab ich davon? vermutlich einen tag lang magen-darm-pobleme (20g als "single shot" ist kein "lerchalschas") und ansonst nur einen einmaligen, kurzfristigen HGH-peak, dessen anabole wirksamkeit man erstens von vornherein nicht überschätzen sollte (wenn man ihn mit HGH-substitution vergleicht) und der nur ein kurzfristiges "strohfeuer" ist...

welche konsequenz hat dieses ergebnis? soll man jetzt täglich 20 g als einzeldosis einnehmen? nur vor einem wettkampf? über einen längeren zeitraum würde man nur einen teuren urin erzeugen ;-)

also mich reisst dieses paper nicht gerade vom hocker. es hat meinen kreatin-horizont nicht sehr erweitert.

von der gleichen arbeitsgruppe gibt's noch eins über den nierenfunktionsparameter kreatinin (und wieder einmal heisst es "further investigations are required..."):





Life Sci 1999 Oct 29;65(23):2463-70



Acute creatine ingestion in human: consequences on serum creatine and creatinine

concentrations.



Schedel JM, Tanaka H, Kiyonaga A, Shindo M, Schutz Y.



Institute of Physiology, Faculty of Medicine, Lausanne University, Switzerland.

Jean-Marc.Schedel@iphysiol.unil.ch



The aim of the study was to explore the effect of an acute dose of creatine (Cr)

ingestion on serum Cr and serum creatinine (Crn) concentrations. Sixteen healthy

subjects ingested a single dose of Cr (20 g) followed by the measurement of

serum Cr and Crn concentration for 3 h up to a maximum of 6 h (n=6). In response

to Cr ingestion a large rise in serum Cr concentration was observed (by 50

folds) occurring approximately 2 1/2h after the ingestion (peak value of 2.17

+/- 0.66 mmol x l(-1)). We also found a moderate but significant rise in serum

Crn concentration averaging 13 % after 3 h (peak value at 99.5 +/- 10.5 micromol

x l(-1)). A dose response curve obtained in two case studies, in whom different

doses of Cr were ingested (0, 2.5, 5, 10, 15, 20 g and 0, 10, 20, 30 g), showed

that serum Cr concentration as well as the peak time increased linearly with Cr

ingestion. In addition, acute Crn ingestion (5 g) resulted in a substantial

increase in serum Crn concentration (by 10 folds) but led to a minor rise in

serum Cr concentration (by 2 folds). These results suggest that when acute doses

of Cr are ingested in humans, the degree of conversion of exogenous Cr to Crn in

the stomach and the gut can be considered as negligible following the first 6 h

of ingestion. However, further studies are required to explore the prolonged

effect of Cr on Crn metabolism.



PMID: 10622230 [PubMed - indexed for MEDLINE]

[klaus]

ich zumindest würd 20g nicht gut vertragen,hab mir mal beim aufladen gedacht,ich nehm 2x 15g....und musste den ganzen tag aufpassen,das ich mich nur wenige meter vom topf entfern;-))))

grüsse,klaus

[kurt]

man nennt das eine "osmotische diarrhoe" ;-))

gruss, kurt





klaus schrieb:

> ich zumindest würd 20g nicht gut vertragen,hab mir mal beim aufladen gedacht,ich nehm 2x 15g....und musste den ganzen tag aufpassen,das ich mich nur wenige meter vom topf entfern;-))))

> grüsse,klaus